| |
|
|
 | Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
|
Registro completo
|
|
Biblioteca (s) : |
INIA Las Brujas. |
|
Fecha : |
30/06/2023 |
|
Actualizado : |
30/06/2023 |
|
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
|
Autor : |
GIANNITTI, F.; GARCÍA, J. P.; ADAMS, V.; ARMENDANO, J.; BEINGESSER, J.; ROOD, J.; UZAL, F. A. |
|
Afiliación : |
FEDERICO GIANNITTI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; JORGE P. GARCÍA, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Buenos Aires, Argentina; VICKI ADAMS, Monash University, Parkville, Victoria, Australia; JOAQUÍN I. ARMENDANO, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Buenos Aires, Argentina; JULIANN BEINGESSER, California Animal Health and Food Safety Laboratoy, University of California at Davis, San Bernardino, CA; JULIAN I. ROOD, Monash University, Parkville, Victoria, Australia; FRANCISCO A. UZAL, Monash University, Parkville, Victoria, Australia. |
|
Título : |
Experimental acute Clostridium perfringens type D enterotoxemia in sheep is not characterized by specific renal lesions. |
|
Complemento del título : |
Infectious Disease - Original Article. |
|
Fecha de publicación : |
2023 |
|
Fuente / Imprenta : |
Veterinary Pathology. 2023, vol.60(4):412-419. https://doi.org/10.1177/03009858231171669 |
|
ISSN : |
0300-9858 (print); 1544-2217 (online). |
|
DOI : |
10.1177/03009858231171669 |
|
Idioma : |
Inglés |
|
Notas : |
Article history: First published online May 12, 2023. -- Corresponding Author: Francisco A. Uzal, California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California at Davis, 105 W CVentral Ave, San Bernardino, CA 92408, USA. Email: fauzal@ucdavis.edu -- Funding: This work was supported by grant R01 AI056177 from the National Institute of Allergy and Infectious Diseases (NIAID). Research at Monash University was also supported by funding provided by the Australian Research Council to the Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics (grant no. CE0562063). -- |
|
Contenido : |
ABSTRACT.- Type D enterotoxemia, caused by Clostridium perfringens epsilon toxin (ETX), is one of the most economically important clostridial diseases of sheep. Acute type D enterotoxemia is characterized by well-documented lesions in the nervous, cardiocirculatory, and pulmonary systems. However, discrepancies and confusion exist as to whether renal lesions are part of the spectrum of lesions of this condition, which is controversial considering that for many decades it has been colloquially referred to as "pulpy kidney disease". Here, the authors assess renal changes in an experimental model of acute type D enterotoxemia in sheep and evaluate the possible role of ETX in their genesis. Four groups of 6 sheep each were intraduodenally inoculated with either a wild-type virulent C. perfringens type D strain, an etx knockout mutant unable to produce ETX, the etx mutant strain complemented with the wild-type etx gene that regains the ETX toxin production, or sterile culture medium (control group). All sheep were autopsied less than 24 hours after inoculation; none of them developed gross lesions in the kidneys. Ten predefined histologic renal changes were scored in each sheep. The proportion of sheep with microscopic changes and their severity scores did not differ significantly between groups. Mild intratubular medullary hemorrhage was observed in only 2 of the 12 sheep inoculated with the wild-type or etx-complemented bacterial strains, but not in the 12 sheep of the other 2 groups. The authors conclude that no specific gross or histologic renal lesions are observed in sheep with experimental acute type D enterotoxemia. © The Author(s) 2023 MenosABSTRACT.- Type D enterotoxemia, caused by Clostridium perfringens epsilon toxin (ETX), is one of the most economically important clostridial diseases of sheep. Acute type D enterotoxemia is characterized by well-documented lesions in the nervous, cardiocirculatory, and pulmonary systems. However, discrepancies and confusion exist as to whether renal lesions are part of the spectrum of lesions of this condition, which is controversial considering that for many decades it has been colloquially referred to as "pulpy kidney disease". Here, the authors assess renal changes in an experimental model of acute type D enterotoxemia in sheep and evaluate the possible role of ETX in their genesis. Four groups of 6 sheep each were intraduodenally inoculated with either a wild-type virulent C. perfringens type D strain, an etx knockout mutant unable to produce ETX, the etx mutant strain complemented with the wild-type etx gene that regains the ETX toxin production, or sterile culture medium (control group). All sheep were autopsied less than 24 hours after inoculation; none of them developed gross lesions in the kidneys. Ten predefined histologic renal changes were scored in each sheep. The proportion of sheep with microscopic changes and their severity scores did not differ significantly between groups. Mild intratubular medullary hemorrhage was observed in only 2 of the 12 sheep inoculated with the wild-type or etx-complemented bacterial strains, but not in the 12 sheep of the other 2 ... Presentar Todo |
|
Palabras claves : |
Clostridium perfringens type D; Enterotoxemia; ETX; Experimental infection; Kidneys; PLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA; Renal pathology; Sheep. |
|
Asunto categoría : |
L10 Genética y mejoramiento animal |
|
Marc : |
LEADER 03352naa a2200325 a 4500
001 1064216
005 2023-06-30
008 2023 bl uuuu u00u1 u #d
022 $a0300-9858 (print); 1544-2217 (online).
024 7 $a10.1177/03009858231171669$2DOI
100 1 $aGIANNITTI, F.
245 $aExperimental acute Clostridium perfringens type D enterotoxemia in sheep is not characterized by specific renal lesions.$h[electronic resource]
260 $c2023
500 $aArticle history: First published online May 12, 2023. -- Corresponding Author: Francisco A. Uzal, California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California at Davis, 105 W CVentral Ave, San Bernardino, CA 92408, USA. Email: fauzal@ucdavis.edu -- Funding: This work was supported by grant R01 AI056177 from the National Institute of Allergy and Infectious Diseases (NIAID). Research at Monash University was also supported by funding provided by the Australian Research Council to the Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics (grant no. CE0562063). --
520 $aABSTRACT.- Type D enterotoxemia, caused by Clostridium perfringens epsilon toxin (ETX), is one of the most economically important clostridial diseases of sheep. Acute type D enterotoxemia is characterized by well-documented lesions in the nervous, cardiocirculatory, and pulmonary systems. However, discrepancies and confusion exist as to whether renal lesions are part of the spectrum of lesions of this condition, which is controversial considering that for many decades it has been colloquially referred to as "pulpy kidney disease". Here, the authors assess renal changes in an experimental model of acute type D enterotoxemia in sheep and evaluate the possible role of ETX in their genesis. Four groups of 6 sheep each were intraduodenally inoculated with either a wild-type virulent C. perfringens type D strain, an etx knockout mutant unable to produce ETX, the etx mutant strain complemented with the wild-type etx gene that regains the ETX toxin production, or sterile culture medium (control group). All sheep were autopsied less than 24 hours after inoculation; none of them developed gross lesions in the kidneys. Ten predefined histologic renal changes were scored in each sheep. The proportion of sheep with microscopic changes and their severity scores did not differ significantly between groups. Mild intratubular medullary hemorrhage was observed in only 2 of the 12 sheep inoculated with the wild-type or etx-complemented bacterial strains, but not in the 12 sheep of the other 2 groups. The authors conclude that no specific gross or histologic renal lesions are observed in sheep with experimental acute type D enterotoxemia. © The Author(s) 2023
653 $aClostridium perfringens type D
653 $aEnterotoxemia
653 $aETX
653 $aExperimental infection
653 $aKidneys
653 $aPLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA
653 $aRenal pathology
653 $aSheep
700 1 $aGARCÍA, J. P.
700 1 $aADAMS, V.
700 1 $aARMENDANO, J.
700 1 $aBEINGESSER, J.
700 1 $aROOD, J.
700 1 $aUZAL, F. A.
773 $tVeterinary Pathology. 2023, vol.60(4):412-419. https://doi.org/10.1177/03009858231171669
Descargar
Esconder MarcPresentar Marc Completo |
|
Registro original : |
INIA Las Brujas (LB) |
|
|
Biblioteca
|
Identificación
|
Origen
|
Tipo / Formato
|
Clasificación
|
Cutter
|
Registro
|
Volumen
|
Estado
|
Volver
|
|
|
| Registros recuperados : 22 | |
| 5. |  | CARMO, P.M.S.D.; UZAL , F.A.; PEDROSO, P.M.O.; RIET-CORREA, F. Conidiobolomycosis, cryptococcosis, and aspergillosis in sheep and goats: a review. Journal of Veterinary Diagnostic Investigation, Vol. 32, Issue 6, pag.826-834, Nov. 2020. Doi: https://doi.org/10.1177/1040638720958338 Article history: First Published September 14, 2020.| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA La Estanzuela. |
|    |
| 7. | | DONCEL, B.; CASTELLS, M.; MAYA, L.; FRAGA, M.; UZAL, F.A; COLINA, R.; GIANNITTI, F. Encefalitis asociada a astrovirus bovino neurotrópico, ¿una enfermedad subdiagnosticada en Sudamérica?.[Neurotropic bovine astrovirus-associated encephalitis: An underdiagnosed disease in South America?]. Revista Argentina de Microbiologia, Volume 54, Pages 100-105, 2022. OPEN ACCESS. Doi: https://doi.org/10.1016/j.ram.2021.01.00 Article history: Recibido el 15 de julio de 2020/ Aaceptado el 24 de enero de 2021./Disponible en Internet el 18 junio 2021. Autor para correspondencia: Correo electrónico: fgiannitti@inia.org.uy (F. Giannitti). Este trabajo fue...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA La Estanzuela. |
|  |
| 9. | | GIANNITTI, F.; GARCÍA, J. P.; ADAMS, V.; ARMENDANO, J.; BEINGESSER, J.; ROOD, J.; UZAL, F. A. Experimental acute Clostridium perfringens type D enterotoxemia in sheep is not characterized by specific renal lesions. Infectious Disease - Original Article. Veterinary Pathology. 2023, vol.60(4):412-419. https://doi.org/10.1177/03009858231171669 Article history: First published online May 12, 2023. -- Corresponding Author: Francisco A. Uzal, California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California at Davis, 105 W CVentral Ave,...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas. |
| |
| 11. | | CARVALLO, F.R.; UZAL, F.A.; FLORES, C.; DIAB, S.S.; GIANNITTI, F.; CROSSLEY, B.; WÜNSCHMANN, A. Alimentary necrobacillosis in alpacas. Journal of Veterinary Diagnostic Investigation,2020,Mar;32(2):339-343. Doi: https://doi.org/10.1177/1040638720906409 Article history: Article first published online: February 18, 2020/ Issue published: March 1, 2020.
Corresponding Author: Francisco R. Carvallo, Department of Biomedical Sciences and Pathobiology, Virginia?Maryland College of Veterinary....| Biblioteca(s): INIA La Estanzuela. |
| |
| 12. | | GIANNITTI, F.; GARCÍA, J.P.; ROOD, J.I.; ADAMS, V.; ARMENDANO, J.I.; BEINGESSER, J.; UZAL, F.A. Cardiopulmonary Lesions in Sheep Produced by Experimental Acute Clostridium Perfringens Type D Enterotoxemia. Veterinay Pathology, volumen 58, number 1, pag. 103-113, 2021. Doi: https://doi.org/10.1177/0300985820965554 Article history: First Published October 15, 2020. Corresponding Author:Francisco A. Uzal, Email: fuzal@cahfs.ucdavis.edu. The author(s) disclosed receipt of the following financial support for the research, authorship, and/or...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA La Estanzuela. |
| |
| 13. | | GARCIA, J.P; GIANNITTI, F.; FINNIE, J.W.; MANAVIS, J. .; BEINGESSER, J.; ADAMS ,V.; ROOD, J.I.; UZAL, F.A. Comparative Neuropathology of Ovine Enterotoxemia Produced by Clostridium perfringens Type D Wild-Type Strain CN1020 and Its Genetically Modified Derivatives. Veterinary Pathology, 2015, v.52.n.6. p.1250-1253, 2015.| Biblioteca(s): INIA La Estanzuela. |
| |
| 15. | | GIANNITTI, F.; CAFFARENA, D.; PESAVENTO, P.; UZAL, F.A.; MAYA, L.; FRAGA, M.; COLINA, R.; CASTELLS, M. The first case of bovine astrovirus-associated encephalitis in the southern hemisphere (Uruguay), uncovers evidence of viral introduction to the Americas from Europe. Frontiers in Microbiology, volumen 10, Article 1240, 04 June 2019. [OPEN ACCESS].Doi: https://doi.org/10.3389/fmicb.2019.01240 Article history: Received: 22 March 2019//Accepted: 17 May 2019//Published: 04 June 2019. This work was funded by Grants PL-015 N-15156 from INIA and 158 from the ?Programa de Iniciación a la Investigación 2017? from ?Comisión Sectorial...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA La Estanzuela. |
| |
| 16. | | UZAL, F.A.; STOVER, S.; MORGAN, J.; FINO, C.; DIAB, S.; GIANNITTI, F.; HILL, A.E.; ARTHUR, R. Sudden death of racehorses in California: what is new?. [abstract] In: Proceedings of the American Association of Veterinary Laboratory Diagnosticians (AAVLD), 65th and United States Animal Health Association (USAHA) Annual Meeting, 126th, Minneapolis, Minnesota, USA. Oct. 6-12, 2022. pp.118. AAVLD 2022, 65th Annual Meeting "Technological Advances in Veterinary Diagnosis: what's here and what's on the horizon?".| Tipo: Abstracts/Resúmenes |
| Biblioteca(s): INIA Las Brujas. |
| |
| 17. | | MACÍAS-RIOSECO, M.; RIET-CORREA, F.; MILLER, M.M.; SONDGEROTH, K.; FRAGA, M.; SILVEIRA, C.S.; UZAL, F.A.; GIANNITTI, F. Bovine abortion caused by Coxiella burnetii : report of a cluster of cases in Uruguay and review of the literature. Journal of Veterinary Diagnostic Investigation; Jul 2019, v. 31, n. 4, p.634-639. Article history: Article first published online: June 10, 2019//Issue published: July 1, 2019.| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA La Estanzuela. |
| |
| 18. | | MACÍAS-RIOSECO, M.; MIRAZO ,S.; UZAL, F.A.; FRAGA, M.; SILVEIRA, C.S.; MAYA, L.; RIET-CORREA, F.; ARBIZA, J.; COLINA, R.; ANDERSON ,M.L.; GIANNITTI, F. Fetal Pathology in an Aborted Holstein Fetus Infected With Bovine Parainfluenza Virus-3 Genotype A. Veterinary Pathology [Vet Pathol], 2018 Sep 24, p. 300985818798117. Article History:Date Created: 20180925 //Latest Revision: 20180924.| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA La Estanzuela. |
| |
| 19. | | GARCÍA, J.A.; LIVIO, J.M.; MATTO, C.; DUTRA, F.; SCIOLI, V.; GIANNITTI, F.; LANGSTON, J.; POPPENGA, R.H.; CANTÓN, G.J.; UZAL, F.A. Pollen beetle (Astylus atromaculatus)-associated gastroenteric disease in cattle: report of 6 natural outbreaks. Full Scientific Report. Journal of Veterinary Diagnostic Investigation, 2024, Volume 36, Issue 1, Pages 95-102. https://doi.org/10.1177/10406387231215756 Article history: Article first published online: November 29, 2023; Issue published: January 2024. -- Correspondence: Uzal, F.A.; California Animal Health and Food Safety Laboratory, San Bernardino branches, School of Veterinary Medicine,...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas. |
| |
| 20. | | DORSCH, M.; CASAUX, M.L.; CALLEROS, L.; ARÁOZ, V.; CAFFARENA, D.; MONESIGLIO, M.C.; BARCELLOS, M.; SILVEIRA, C.S.; PERDOMO, T.; BANCHERO, G.; UZAL, F.A.; FRAGA, M.; GIANNITTI, F. Corrigendum to "Placentitis and abortion caused by a multidrug resistant strain of Campylobacter fetus subspecies fetus in a sheep in Uruguay". (Revista Argentina de Microbiologia (2022) 54(1) (25-30), (S0325754121000389), (10.1016/j.ram.2021.02.005)). Erratum. Revista Argentina de Microbiologia. 2023, Volume 55, Issue 4, Pages 397-398. https://doi.org/10.1016/j.ram.2023.11.002 -- OPEN ACCESS. Article history: Available online 21 December 2023; Version of Record 21 December 2023. -- Correspondence: Giannitti, F.; Plataforma de Investigación en Salud Animal, Instituto Nacional de Investigación Agropecuaria (INIA), Ruta 50 Km 11,...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas. |
|  |
| Registros recuperados : 22 | |
|
| Expresión de búsqueda válido. Check! |
|
|
